Description

Product Description

Riztunitide is a synthetic peptide that has been identified as a promising candidate for the study of inflammatory processes and immune system modulation. Inflammation is a highly conserved biological response, essential for host defense against pathogens and injury repair. However, uncontrolled or chronic inflammation is a hallmark of numerous pathological conditions, including autoimmune diseases, metabolic syndromes, neuroinflammation, cardiovascular disorders, and cancer.

As an anti-inflammatory peptide, Riztunitide has drawn attention from researchers due to its potential ability to:

• Suppress excessive pro-inflammatory cytokine production (e.g., TNF-α, IL-1β, IL-6).

• Enhance anti-inflammatory mediators such as IL-10.

• Regulate the activation of innate immune cells (macrophages, neutrophils, dendritic cells).

• Interfere with chronic inflammatory signaling pathways such as NF-κB, JAK/STAT, and MAPK.

Importance of Anti-Inflammatory Peptides

Conventional anti-inflammatory agents, such as NSAIDs and corticosteroids, often carry risks of gastrointestinal, renal, and metabolic side effects. Peptides like Riztunitide offer advantages:

• High specificity – targeting defined molecular pathways.

• Reduced systemic toxicity – biodegradable and less likely to accumulate in tissues.

• Versatility – can be engineered for enhanced stability, bioavailability, or conjugation with drug carriers.

Research Applications of Riztunitide

• Autoimmune Disease Models: Potential for investigating mechanisms in rheumatoid arthritis, lupus, and inflammatory bowel disease (IBD).

• Neuroinflammation Studies: Useful in research on Alzheimer’s disease, multiple sclerosis, and Parkinson’s disease.

• Cardiovascular Inflammation: Exploring its role in atherosclerosis and myocardial injury.

• Cancer Research: Chronic inflammation drives tumor microenvironment remodeling; Riztunitide may provide new insights.

• Drug Delivery & Peptide Engineering: Its structure may inspire next-generation bioactive peptides.

By serving as a tool for basic science, translational medicine, and therapeutic discovery, Riztunitide expands the toolkit available for inflammation research.

Product Specifications

Extended Notes

• Purity: High analytical validation ensures consistent results in experimental systems.

• Solubility Profile: Compatible with both in vitro assays and in vivo models.

• Stability: Lyophilized form allows extended shelf-life, with minimal degradation.

• Research Versatility: Can be studied as a free peptide, nanoparticle conjugate, or fusion protein.

Mechanism of Action

The anti-inflammatory activity of Riztunitide is attributed to its regulation of cytokine expression and intracellular signaling cascades.

1. Cytokine Modulation

   • Downregulates TNF-α, IL-1β, IL-6 production.

   • Upregulates IL-10, a key anti-inflammatory cytokine.

2. Signal Pathway Interference

   • NF-κB inhibition: Prevents nuclear translocation of NF-κB, reducing pro-inflammatory gene transcription.

   • JAK/STAT modulation: Alters STAT3 activation, balancing immune responses.

   • MAPK regulation: Dampens ERK and p38 MAPK pathways associated with inflammation.

3. Innate Immune Cell Regulation

   • Modulates macrophage polarization from M1 (pro-inflammatory) to M2 (anti-inflammatory) phenotype.

   • Suppresses neutrophil overactivation, thereby limiting tissue damage.

4. Adaptive Immunity Balance

   • Influences T-cell subsets, potentially reducing Th17-mediated autoimmunity.

This multi-faceted mechanism highlights Riztunitide’s value in modeling complex immune-inflammatory networks in chronic disease.

Side Effects

As Riztunitide is for research use only, comprehensive safety data is not established. However, based on the pharmacology of similar peptides, potential considerations include:

• Immune Suppression: Over-inhibition of inflammation could increase susceptibility to infections.

• Allergic Reactions: Peptides may cause hypersensitivity responses in some animal models.

• Off-Target Effects: Possible unintended modulation of cytokines outside the target pathway.

• Dose-Dependent Toxicity: High concentrations may affect cellular viability in vitro.

Laboratory Safety Notes

• Handle with appropriate protective equipment.

• Dispose of unused material in compliance with biosafety protocols.

• Not intended for diagnostic or therapeutic use in humans.

Disclaimer

For laboratory research use only. Not for human, veterinary, or clinical use.

Keywords

Riztunitide, anti-inflammatory peptide, immune regulation, cytokine inhibitor, NF-κB pathway, autoimmune research, inflammation modulator.

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