Description

Product Description

Excitin 1 (CAS 17136-25-3) is a bioactive central nervous system (CNS) peptide characterized by its ability to penetrate the blood-brain barrier and modulate neurochemical homeostasis. Unlike many neuropeptides that are rapidly degraded in the gastrointestinal tract or unable to access the CNS, Excitin 1 demonstrates oral bioavailability and robust CNS permeability, making it a rare and significant model compound for brain-targeted peptide research.

As a neuromodulatory peptide, Excitin 1 alters the concentrations of monoamines (dopamine, serotonin, norepinephrine) and amino acids (glutamate, GABA, aspartate, glycine) within specific brain regions. These biochemical alterations correspond to measurable behavioral changes in experimental animals, suggesting a profound impact on neuronal communication and synaptic plasticity.

Excitin 1 has been explored in preclinical models for its ability to influence mood, cognition, arousal, and motor function, positioning it as a potential lead compound for developing new neuropsychiatric and neuroprotective agents. Research indicates that Excitin 1 may regulate monoaminergic pathways in the hypothalamus, striatum, and hippocampus, producing both stimulatory and modulatory effects depending on dosage and timing.

In rat models, administration of Excitin 1 leads to dose-dependent behavioral activation, accompanied by changes in dopamine turnover and serotonin metabolism. Furthermore, alterations in amino acid neurotransmitters suggest that Excitin 1 exerts complex neurotransmitter cross-talk effects, integrating excitatory and inhibitory signaling networks.

Its oral efficacy, neurochemical versatility, and behavioral relevance make Excitin 1 a valuable experimental neuropharmacological tool for:

• Studying monoamine regulation in CNS pathways

• Investigating peptide transport across the blood-brain barrier

• Exploring molecular mechanisms of behavioral modulation

• Developing CNS-active peptide therapeutics

• Understanding peptide-mediated neurotransmission balance

Researchers utilize Excitin 1 to examine how peripheral peptides influence central neurochemical networks and to design derivatives that retain CNS activity with improved receptor selectivity.

Overall, Excitin 1 serves as an important link between peptide pharmacology, neurochemistry, and behavioral neuroscience — offering deep insights into the interface between biochemical signaling and behavioral outcomes.

Product Specifications

Synonyms

• Excitin peptide

• CNS neuroactive peptide

• Excitin-1 neurochemical modulator

• Brain-penetrant behavioral peptide

Mechanism of Action

Excitin 1 acts through complex modulation of central neurotransmission, primarily influencing monoaminergic and amino acid-based signaling pathways. After oral absorption, the peptide crosses the blood-brain barrier (BBB) through either receptor-mediated transcytosis or diffusion via peptide transporters expressed on endothelial cells.

Once within the CNS, Excitin 1 modifies monoamine concentrations — elevating or reducing levels of dopamine (DA), norepinephrine (NE), and serotonin (5-HT) in distinct brain regions. These neurotransmitters play central roles in regulating mood, alertness, motivation, and autonomic responses. The peptide’s action may involve modulation of tyrosine hydroxylase activity, monoamine oxidase (MAO) activity, or alterations in presynaptic vesicular release.

Simultaneously, Excitin 1 affects amino acid neurotransmitters, notably glutamate and GABA, thereby influencing the excitatory/inhibitory balance in cortical and subcortical circuits. This dual regulatory role contributes to its behavioral outcomes — ranging from increased locomotor activity and wakefulness to mood stabilization and improved adaptive responses.

At the cellular level, Excitin 1 likely interacts with membrane receptors or second-messenger cascades such as cAMP, PKA, or Ca2+-dependent pathways, altering synaptic transmission and neuroplasticity. It may also impact gene expression related to synaptic proteins, neurotrophic factors, or receptor subunits involved in long-term potentiation (LTP) and depression (LTD).

The net effect of Excitin 1 is a fine-tuned neurochemical rebalancing, resulting in adaptive behavioral and neurophysiological modulation. Its CNS penetration and oral availability distinguish it from conventional peptides, providing an exceptional model to study neuropeptide pharmacodynamics and neurochemical-behavioral coupling.

Side Effects / Safety Notes

Excitin 1 is intended for research use only. To date, no toxicity data in humans are available. In laboratory animal studies, high doses may produce transient hyperactivity or mild autonomic responses related to altered neurotransmitter turnover. It should not be used in humans or animals for therapeutic purposes. Appropriate protective equipment and biosafety procedures should be used when handling the compound.

Disclaimer

All compounds are provided exclusively for laboratory research use. They are not intended for clinical, diagnostic, or therapeutic applications. Data and product specifications are subject to change based on ongoing research findings.

Keywords

Excitin 1, CNS peptide, neuroactive peptide, monoamine modulator, brain-penetrating peptide, oral peptide, peptide supplier, research chemicals manufacturer, custom peptide synthesis, neuroscience research peptide, behavioral neurochemistry compound

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