Urcosimod | CAS 1610366-43-2 | Immunomodulator and Anti-Inflammatory Research Compound

Description

Product Description

Urcosimod (CAS 1610366-43-2), also known as OK 101, is a well-characterized immunomodulatory compound that plays a central role in regulating innate and adaptive immune pathways. It acts as an anti-inflammatory agent capable of modulating cytokine profiles, reducing proinflammatory mediators, and restoring immune homeostasis in experimental models.

As an emerging research tool, Urcosimod has been widely utilized in immunology, inflammation biology, and metabolic disorder studies. It functions by interacting with key immune signaling cascades such as NF-κB, MAPK, and JAK/STAT pathways, leading to suppression of inflammatory cytokine release (e.g., TNF-α, IL-1β, IL-6) and enhanced production of anti-inflammatory mediators like IL-10.

Preclinical research has demonstrated that Urcosimod helps prevent chronic inflammatory responses and supports tissue repair mechanisms. In macrophage and T-cell co-culture systems, the compound promotes M2 macrophage polarization and regulatory T-cell (Treg) activation, contributing to immune tolerance.

Urcosimod is particularly valuable for studying autoimmune diseases, arthritis models, inflammatory bowel disease, and systemic inflammation syndromes. In addition, its immunoregulatory properties make it a promising tool for mechanistic research in immunometabolism and inflammation-driven oncogenesis.

Overall, Urcosimod provides researchers with a versatile small-molecule platform to investigate the molecular basis of inflammation, cytokine signaling, and immune modulation in various disease contexts.

Product Specifications

Mechanism of Action

Urcosimod (OK 101) functions primarily as a modulator of inflammatory and immune signaling cascades. The compound suppresses the activation of proinflammatory transcription factors, notably NF-κB and AP-1, which regulate the expression of cytokines, chemokines, and adhesion molecules.

Through interference with the TLR4–MyD88–NF-κB axis, Urcosimod attenuates the production of inflammatory cytokines such as TNF-α, IL-1β, and IL-6, while promoting anti-inflammatory mediators like IL-10 and TGF-β. This dual action rebalances immune responses, shifting the profile from a proinflammatory to an anti-inflammatory state.

Urcosimod also modulates macrophage phenotype by inducing M2-like polarization, which contributes to tissue repair and regeneration. Furthermore, it downregulates reactive oxygen species (ROS) generation and prevents oxidative stress-mediated cellular injury.

In T-cell assays, Urcosimod has been shown to inhibit effector T-cell activation while favoring the expansion of regulatory T cells (Tregs), thus supporting immune tolerance mechanisms. This makes it a valuable agent for exploring therapies for autoimmune and inflammatory disorders at the molecular level.

Side Effects

In experimental and preclinical studies, Urcosimod has shown low cytotoxicity and good biocompatibility at research concentrations. However, excessive dosing or prolonged exposure may lead to:

• Transient suppression of certain immune cell populations

• Altered cytokine balance

• Reversible metabolic enzyme modulation

No genotoxic, mutagenic, or teratogenic effects have been reported in laboratory use. All handling should be conducted under standard safety and biosafety protocols.

Disclaimer

All products are intended for laboratory research use only. Not for human or veterinary use. Researchers must ensure appropriate handling, storage, and disposal according to institutional and regulatory guidelines.

Keywords

Urcosimod, OK 101, immunomodulator peptide, anti-inflammatory research compound, cytokine regulator, NF-κB inhibitor, immune modulation, inflammation model, pharmacological research, laboratory reagent

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