Filimelnotide Acetate | CAS Pending | Melanocortin Receptor Agonist for Endocrine and Metabolic Research

Description

Product Description

Filimelnotide acetate is a synthetic peptide that functions as a melanocortin receptor (MC) agonist, targeting receptors such as MC1R, MC3R, and MC4R, which are essential for energy homeostasis, pigmentation control, and neuroendocrine regulation.

This compound mimics the biological activity of endogenous melanocortins, including α-MSH and ACTH derivatives, by binding to G protein–coupled melanocortin receptors. Activation of these receptors triggers downstream signaling through cyclic AMP (cAMP) and protein kinase A (PKA) pathways, leading to modulation of metabolic rate, appetite control, and inflammatory balance.

In research contexts, Filimelnotide acetate is widely employed to investigate melanocortin system dynamics, obesity-related signaling, and neuroendocrine peptide regulation. Studies have shown that the compound stimulates melanocortin-induced pathways associated with thermogenesis, fat oxidation, and appetite suppression.

Beyond metabolic studies, Filimelnotide acetate also offers value in pigmentation research, as the melanocortin system influences melanin biosynthesis through MC1R activation. This makes it an important molecular tool for elucidating pigment cell biology and photoresponse regulation.

Overall, Filimelnotide acetate provides researchers with a precise and reliable agent to explore the roles of melanocortin receptors in both central nervous system (CNS) and peripheral endocrine signaling.

Product Specifications

Mechanism of Action

Filimelnotide acetate exerts its biological activity by binding and activating melanocortin receptors (MC1R–MC5R), which are members of the G protein–coupled receptor (GPCR) family. Upon receptor activation, Filimelnotide stimulates adenylate cyclase activity, leading to elevated intracellular cAMP levels. This initiates downstream signaling cascades involving PKA, CREB, and MAPK pathways.

In hypothalamic neurons, the activation of MC3R and MC4R contributes to appetite suppression and energy expenditure through modulation of pro-opiomelanocortin (POMC) neuron activity. In peripheral tissues, MC1R activation enhances melanin synthesis and provides protective antioxidant functions in melanocytes.

Filimelnotide’s engagement with the melanocortin system allows researchers to explore regulatory mechanisms behind metabolic homeostasis, stress response, and skin pigmentation control. Its receptor selectivity and potency make it a highly effective molecular tool for dissecting receptor-ligand dynamics in the melanocortin pathway.

Side Effects

In preclinical and in vitro studies, Filimelnotide acetate demonstrates excellent tolerability and minimal off-target effects. However, potential dose-dependent effects observed in laboratory settings may include:

• Transient cellular stress responses

• Minor fluctuations in intracellular calcium signaling

• Temporary modulation of cAMP levels

No evidence of cytotoxicity or genotoxicity has been reported. Standard laboratory precautions should be applied during handling and dissolution.

Disclaimer

All products are intended for laboratory research use only. Not for human or veterinary use. Researchers must follow institutional biosafety and chemical handling guidelines.

Keywords

Filimelnotide acetate, melanocortin receptor agonist, MC4R activator, metabolism research peptide, endocrine signaling, pigmentation regulation, neuroendocrine peptide, obesity model, GPCR agonist, peptide ligand

Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

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