NN1213 | Peptide 21 | Long-Acting Amylin Receptor Agonist for Anti-Obesity Research

Description

Product Description

NN1213, also known as Peptide 21, is a long-acting human amylin analog designed for enhanced receptor selectivity, metabolic stability, and prolonged pharmacological activity. It exhibits potent agonism at human and rodent Amylin receptors (hAMY3R and rAMY3R), with EC₅₀ values of 0.177 nM and 0.262 nM respectively, making it one of the most potent amylin mimetics developed for metabolic research.

Amylin, a pancreatic β-cell hormone, plays a crucial role in energy balance, gastric emptying, and appetite regulation. However, native amylin is limited by aggregation and rapid degradation. NN1213 was engineered through targeted sequence modification to resist enzymatic breakdown and reduce fibrillogenic tendencies while retaining full biological activity.

In experimental models, NN1213 has been shown to suppress food intake, delay gastric emptying, and reduce body weight gain in rats and dogs, demonstrating robust anorectic and metabolic regulatory effects. These properties make NN1213 a valuable tool compound for investigating amylin receptor signaling, appetite modulation, and neuroendocrine pathways in obesity and metabolism.

At the molecular level, NN1213 binds to the AMY3 receptor complex, a heterodimer composed of calcitonin receptor (CTR) and receptor activity-modifying protein 3 (RAMP3). Activation of this complex triggers intracellular cAMP accumulation and downstream signaling that suppresses hypothalamic orexigenic neurons while enhancing satiety pathways.

Beyond its primary use in appetite research, NN1213 is also applied in comparative pharmacology, GPCR signaling analysis, and peptide optimization studies for next-generation metabolic therapeutics.

Product Specifications

Mechanism of Action

NN1213 functions as a selective agonist of the Amylin receptor (AMY3R), a G protein-coupled receptor (GPCR) complex consisting of the calcitonin receptor (CTR) and receptor activity-modifying protein 3 (RAMP3). Upon receptor binding, NN1213 induces cAMP-mediated intracellular signaling, which in turn modulates neuronal circuits in the hypothalamus associated with appetite suppression and energy homeostasis.

The pharmacological action of NN1213 is characterized by its ability to mimic endogenous amylin while exhibiting improved pharmacokinetic stability and extended half-life. By reducing gastric motility and slowing nutrient absorption, it supports satiety enhancement and glucose regulation in experimental models.

NN1213’s receptor selectivity profile also provides an important platform for dissecting amylin and calcitonin receptor signaling cross-talk, which contributes to understanding metabolic control mechanisms in obesity and type 2 diabetes.

Side Effects

In preclinical research settings, NN1213 is generally well-tolerated. At high concentrations, transient gastrointestinal effects such as reduced gastric emptying or decreased feeding behavior may occur as expected pharmacological responses. No cytotoxic or genotoxic effects have been reported under laboratory use conditions.

Researchers should note that excessive or prolonged receptor activation may cause temporary downregulation of Amylin receptors in vitro. Standard peptide handling and dosage optimization are recommended to maintain experimental accuracy.

Disclaimer

All compounds are provided for laboratory research use only. Not for human consumption, therapeutic, or diagnostic use. Researchers must follow institutional biosafety and chemical handling guidelines.

Keywords

NN 1213, Peptide 21, amylin receptor agonist, AMY3R agonist, long-acting amylin analog, appetite suppression peptide, anti-obesity peptide, metabolic research compound, GPCR peptide agonist, energy regulation peptide

Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

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