Palopegteriparatide | CAS 2222514-07-8 | Long-Acting PTH Prodrug for Hypoparathyroidism Research

Description

Product Description

Palopegteriparatide, also known as Transcon PTH, represents an advanced form of parathyroid hormone replacement designed for long-term regulation of calcium homeostasis. As a PTH 1-34 prodrug, it utilizes a sustained-release linker system that gradually releases active PTH in circulation, providing stable hormonal activity that closely mimics natural secretion patterns.
This compound plays a pivotal role in laboratory research on calcium metabolism, bone remodeling, and parathyroid gland disorders. Unlike conventional peptide PTH analogs requiring frequent administration, Palopegteriparatide ensures prolonged bioavailability and consistent serum calcium maintenance. Its controlled activation eliminates the need for additional calcium or vitamin D supplementation, a breakthrough in experimental models of chronic hypoparathyroidism.
Researchers employ Palopegteriparatide to study molecular pathways regulating bone formation, renal calcium reabsorption, and phosphate balance. The compound has also been valuable in understanding endocrine feedback mechanisms and receptor desensitization under sustained PTH exposure. With its unique pharmacokinetic profile, Palopegteriparatide offers a superior platform for investigating long-term PTH signaling, calcium transport, and systemic mineral metabolism.

Mechanism of Action

Palopegteriparatide functions as a transiently bound prodrug of parathyroid hormone fragment PTH 1-34. The inactive precursor is conjugated to a biodegradable carrier through a proprietary linker, which slowly releases active PTH via controlled hydrolysis. The released peptide binds to PTH1 receptors (PTH1R) in target tissues such as bone and kidney, stimulating cyclic AMP (cAMP) production and activating downstream signaling cascades that regulate calcium and phosphate homeostasis.
In the kidney, PTH1R activation enhances calcium reabsorption and reduces phosphate reabsorption, thereby maintaining electrolyte balance. In bone, PTH stimulates osteoblastic activity and bone remodeling, promoting calcium mobilization when needed.
The sustained PTH release from Palopegteriparatide results in stable serum calcium levels with minimal fluctuations compared to intermittent PTH analog administration. This consistent pharmacological effect has made it a highly valuable compound for mechanistic studies on chronic endocrine control, renal mineral transport, and skeletal metabolism regulation.

Side Effects

In experimental settings, Palopegteriparatide has demonstrated favorable tolerability compared to conventional PTH analogs. However, potential effects observed in model organisms include transient hypercalcemia, mild nausea, and dose-dependent fluctuations in phosphate levels. Chronic exposure at supraphysiologic concentrations may induce skeletal resorption or metabolic imbalance.
Careful titration and monitoring of calcium, phosphate, and renal markers are recommended in research use to prevent potential systemic alterations. The compound should only be handled by trained professionals under controlled laboratory conditions.

Product Specifications

Disclaimer

All products are for laboratory research use only. They are not intended for human or veterinary use, diagnosis, treatment, or consumption.

Keywords

Palopegteriparatide, Transcon PTH, PTH analog, parathyroid hormone prodrug, calcium homeostasis peptide, endocrine peptide, hypoparathyroidism research, bone metabolism regulation

Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

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