Description

Product Description

Copper tripeptide-3 (AHK-Cu) is a synthetic bioactive peptide composed of the tripeptide sequence Ala-His-Lys chelated with copper ions. This compound has gained significant attention in dermatological and cosmetic research due to its remarkable regenerative, anti-aging, and restorative effects on both skin and hair follicles. As a naturally occurring peptide complex derived from the body’s own wound-healing mechanisms, Copper tripeptide-3 represents one of the most advanced biomimetic peptides used in cosmetic science today.

In research applications, Copper tripeptide-3 demonstrates strong efficacy in stimulating dermal cell proliferation, enhancing fibroblast viability, and increasing the synthesis of key extracellular matrix (ECM) proteins such as collagen, elastin, and glycosaminoglycans. These biological effects contribute to improved skin firmness, elasticity, and resilience — essential parameters in anti-aging and skin rejuvenation research.

When applied to the scalp, Copper tripeptide-3 promotes hair follicle vitality by stimulating dermal papilla cell proliferation and prolonging the anagen (growth) phase of the hair cycle. The peptide activates key molecular pathways associated with hair follicle stem cell renewal and oxidative protection, leading to visible increases in hair density and strength in research models.

Furthermore, Copper tripeptide-3 exhibits potent antioxidant and anti-inflammatory activities. It reduces oxidative stress in dermal tissues by upregulating superoxide dismutase and catalase enzyme systems, helping neutralize reactive oxygen species (ROS) responsible for cellular aging. This protective mechanism prevents collagen degradation and limits the inflammatory cascades that accelerate skin aging.

Cosmetic peptide studies have shown that AHK-Cu may also enhance wound healing by improving angiogenesis and accelerating tissue remodeling. It acts as a signal molecule promoting the migration of keratinocytes and fibroblasts toward injury sites, assisting in rapid repair and reducing post-inflammatory pigmentation.

Overall, Copper tripeptide-3 is recognized as a multifunctional peptide with wide-ranging potential in anti-aging, skin regeneration, wound recovery, and hair growth research. Its molecular design provides a stable, non-toxic, and biocompatible platform suitable for integration into advanced cosmetic formulations.

Researchers value Copper tripeptide-3 for its proven ability to mimic natural repair peptides found in human plasma and tissues, offering a reliable biomimetic model for exploring peptide-mediated regeneration mechanisms. With excellent dermal absorption and compatibility, it serves as an ideal candidate for developing next-generation anti-aging and hair-restoration products in the cosmetic peptide field.

Product Specifications

Mechanism of Action

Copper tripeptide-3 acts as a biomimetic signaling molecule that enhances tissue regeneration through copper-mediated enzymatic activation and peptide receptor modulation. The peptide’s Ala-His-Lys (AHK) motif exhibits high affinity for copper ions, forming a stable complex (AHK-Cu) that plays an essential role in cellular repair and antioxidant defense.

1. Stimulation of Collagen and ECM Production

The AHK-Cu complex activates the TGF-β/SMAD pathway and enhances the transcription of collagen types I and III, elastin, and fibronectin genes in fibroblasts. It improves extracellular matrix density and elasticity, resulting in firmer and more youthful-looking skin.

2. Promotion of Hair Growth

Copper tripeptide-3 binds to receptors in dermal papilla cells, stimulating proliferation and prolonging the anagen phase of the hair growth cycle. This process boosts hair follicle activity, increases keratin production, and enhances scalp microcirculation — a key aspect of anti-gray and hair-thickening research.

3. Antioxidant and Anti-inflammatory Modulation

Copper tripeptide-3 upregulates antioxidant enzymes (superoxide dismutase and catalase) and reduces lipid peroxidation. This protects dermal structures from UV-induced oxidative stress, minimizing wrinkle formation and preventing collagen cross-linking.

4. Enhancement of Wound Healing

The peptide accelerates re-epithelialization by stimulating keratinocyte migration and angiogenesis. Copper tripeptide-3 acts as a signaling molecule for endothelial cells, increasing VEGF expression and improving oxygen supply to damaged skin.

5. Activation of SIRT1 and Cellular Longevity Pathways

Copper tripeptide-3 indirectly promotes SIRT1 activation — a critical enzyme linked to mitochondrial health and cellular lifespan. This leads to reduced cellular senescence and enhanced dermal cell vitality, forming the foundation of its anti-aging mechanism.

Side Effects

Copper tripeptide-3 is generally regarded as safe for laboratory and cosmetic peptide research. No cytotoxicity or significant irritation has been reported in standard in vitro or ex vivo models.
Potential mild effects observed in high concentrations may include:

• Slight transient redness in sensitive tissue models

• Minor alteration in copper metabolism markers at supra-physiological levels

All effects are reversible and dose-dependent. As with all bioactive materials, Copper tripeptide-3 should be handled under controlled laboratory conditions and used strictly for research purposes.

Keywords

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Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.