Description

Product Description

Chemotactic Domain of Elastin (CDE) is a biologically active peptide fragment derived from elastin, a critical extracellular matrix (ECM) protein that maintains tissue elasticity and structural integrity. This peptide segment exhibits potent chemotactic properties and has been demonstrated to stimulate the migration of specific tumor cells, such as M27 murine lung carcinoma cells.

In tumor microenvironment research, the Chemotactic Domain of Elastin serves as an essential molecular probe for investigating ECM-derived signaling pathways that regulate cancer progression and metastasis. The peptide mimics natural elastin degradation fragments produced by elastases during tissue remodeling, allowing researchers to study how ECM breakdown influences cell motility, invasion, and angiogenesis.

Mechanistically, CDE interacts with elastin-binding protein (EBP) and other cell surface receptors to trigger downstream signaling cascades involving MAPK and PI3K/Akt pathways. These signaling routes are implicated in cytoskeletal reorganization and directional cell movement, key processes in tumor metastasis and inflammatory response.

Beyond oncology, CDE is also valuable in studies on wound healing, vascular remodeling, and fibrosis, where elastin degradation products play a role in cell recruitment and tissue repair. Its defined structure and high bioactivity make it a powerful research tool for exploring ECM–cell communication and receptor–ligand interactions in pathological and regenerative contexts.

Product Specifications

Mechanism of Action

Chemotactic Domain of Elastin functions as an extracellular signaling molecule derived from elastin proteolysis. When released from the parent elastin polymer, this peptide binds to elastin-binding protein (EBP), galectin-3, and integrins on the cell surface, triggering chemotactic signaling.

The engagement of these receptors activates multiple intracellular cascades, including ERK1/2 phosphorylation and PI3K/Akt activation, which promote actin filament rearrangement and directional migration. In cancer cell models, CDE has been shown to increase motility and invasive potential, indicating a crucial role in the metastatic microenvironment.

In addition, CDE contributes to the recruitment of fibroblasts, macrophages, and endothelial cells in wound and inflammatory sites, highlighting its multifunctional chemotactic profile. These properties make it an indispensable model peptide for understanding how ECM fragments regulate cell migration and tissue remodeling in both normal and pathological conditions.

Side Effects

Chemotactic Domain of Elastin is intended strictly for laboratory research use only. There are no known adverse effects under controlled experimental conditions. However, it should not be administered to humans or animals. Researchers must wear appropriate PPE and follow biosafety standards when handling this peptide.

Keywords

Chemotactic Domain of Elastin, Elastin-derived peptide, ECM signaling peptide, tumor chemotaxis research, metastasis model peptide, extracellular matrix degradation, bioactive peptide supplier, high-purity peptides, peptide manufacturer China.

Shipping Guarantee

All Chemotactic Domain of Elastin shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

Chemotactic Domain of Elastin We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.