Description

Product Description

Hexapeptide-11 is a synthetic bioactive peptide originally derived from a natural yeast fermentation process. It consists of a specific sequence of six amino acids that exhibit strong biological signaling activity related to skin regeneration and elasticity. This peptide has become an essential ingredient in cosmetic and dermatological research due to its ability to modulate gene expression associated with extracellular matrix (ECM) production, cellular detoxification, and oxidative stress resistance.

In skin research models, Hexapeptide-11 has demonstrated the ability to improve fibroblast functionality, which plays a critical role in maintaining skin structural integrity. Fibroblasts are responsible for producing collagen, elastin, and glycosaminoglycans—key components that determine skin firmness and smoothness. When fibroblasts are exposed to oxidative stress or UV radiation, their productivity declines, leading to visible aging signs such as wrinkles, sagging, and loss of elasticity. Hexapeptide-11 mitigates these effects by activating specific cellular pathways that delay senescence and support extracellular matrix synthesis.

Molecular research suggests that Hexapeptide-11 influences the TGF-β (Transforming Growth Factor Beta) and MAPK signaling cascades, enhancing the expression of HAS2 (Hyaluronic Acid Synthase 2) and EGR3 (Early Growth Response 3), both crucial for maintaining dermal hydration and structural cohesion. In parallel, the peptide downregulates HYAL2, an enzyme responsible for hyaluronic acid degradation, thereby prolonging the moisture-retaining properties of the skin matrix.

Further studies indicate that Hexapeptide-11 acts as a mimic of natural growth factors, stimulating cellular turnover and increasing epidermal thickness without inducing irritation or inflammation. In in-vitro and ex-vivo skin models, topical formulations containing Hexapeptide-11 have shown measurable improvements in firmness, smoothness, and overall texture after consistent application, supporting its potential as a next-generation anti-aging compound for cosmetic research.

Its antioxidant profile further enhances its appeal as a dermo-cosmetic research material. By reducing ROS (reactive oxygen species) accumulation and improving mitochondrial function, Hexapeptide-11 helps cells maintain energy balance under environmental stress. These benefits make it an ideal candidate for studies focused on photoaging prevention, oxidative protection, and barrier recovery.

Beyond anti-aging research, Hexapeptide-11 also finds utility in the development of formulations aimed at improving scalp health, hair strength, and follicular renewal. It has been incorporated into experimental blends that support collagen remodeling and elasticity in the scalp tissue, which indirectly influences hair anchoring and density.

In cosmetic laboratories and peptide R&D facilities, Hexapeptide-11 is frequently explored in combination with other active peptides such as palmitoyl tripeptides and copper peptides to assess synergistic effects in anti-aging complexes. These combinations often target multiple biological layers—dermal repair, antioxidant defense, hydration enhancement, and pigmentation balance.

Product Specifications

Mechanism of Action

Hexapeptide-11 exerts its bioactive effects primarily through molecular modulation of key dermal signaling pathways that govern fibroblast activity and extracellular matrix maintenance. One of its main mechanisms is the activation of the TGF-β and MAPK cascades, which are central regulators of collagen synthesis and cellular differentiation. By influencing these pathways, Hexapeptide-11 enhances the synthesis of structural proteins like collagen type I and elastin while simultaneously reducing collagen-degrading enzymes such as MMP-1 and MMP-3.

This dual action—stimulating production while reducing degradation—results in a net increase in dermal density and resilience. Research also indicates that Hexapeptide-11 increases mitochondrial energy metabolism, allowing cells to resist oxidative stress and recover faster from UV-induced damage.

In addition, Hexapeptide-11 promotes hyaluronic acid synthesis through the upregulation of HAS2, which plays a major role in skin hydration. By supporting the structural framework of the dermal extracellular matrix, the peptide contributes to visible firmness and elasticity improvement. It also helps prevent premature fibroblast aging by lowering ROS accumulation and enhancing antioxidant enzyme expression (e.g., SOD and catalase).

At the gene expression level, Hexapeptide-11 upregulates several markers associated with tissue renewal and cellular detoxification. Studies show that prolonged exposure to oxidative stress typically shortens fibroblast lifespan, but Hexapeptide-11 counteracts this through activation of EGR3 and suppression of senescence-related pathways.

Furthermore, in anti-aging formulations research, Hexapeptide-11 demonstrates synergistic effects when combined with niacinamide, vitamin C, or copper peptides—amplifying the stimulation of collagen and elastin. This makes it particularly valuable in multi-component skincare research formulations that target complex biological mechanisms of dermal aging.

Side Effects

Hexapeptide-11 is considered non-toxic, non-irritating, and generally well-tolerated in in-vitro and ex-vivo research systems. Studies have not reported cytotoxicity or mutagenic potential at standard laboratory concentrations. Its mild biochemical nature makes it an ideal peptide for testing in sensitive skin research applications.

When formulated in experimental emulsions, Hexapeptide-11 exhibits stable bioactivity and does not interfere with common excipients. However, as with all laboratory reagents, researchers should follow safety data guidelines and institutional chemical handling policies. Direct clinical or therapeutic application is not permitted; it is strictly intended for controlled research use.

Keywords

Hexapeptide-11, anti-aging peptide, collagen synthesis, fibroblast activation, oxidative stress protection, hyaluronic acid, elasticity enhancer, bioactive cosmetic peptide, peptide wholesale China, factory peptide supplier, high-purity cosmetic peptides, China peptide manufacturer, OEM & bulk peptide production.

Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.