Description

Product Description

Acetyl tetrapeptide-2 is a synthetic tetrapeptide engineered to counteract the visible effects of skin aging by restoring the structural integrity of the dermal matrix. As the skin ages, its mechanical properties deteriorate due to the loss of collagen and elastin, two key structural proteins responsible for maintaining firmness, elasticity, and overall tone. Acetyl tetrapeptide-2 acts by upregulating the synthesis of these proteins and enhancing cellular cohesion, thereby improving skin resilience and reducing the appearance of sagging and wrinkles.

This peptide exhibits potent anti-aging activity by promoting fibroblast proliferation and stimulating the synthesis of dermal extracellular matrix (ECM) components such as collagen type I, III, and elastin. By targeting the molecular pathways involved in skin architecture, Acetyl tetrapeptide-2 rejuvenates the skin’s biomechanical properties and enhances resistance to external stressors such as UV exposure, oxidative damage, and pollution.

The mechanism of Acetyl tetrapeptide-2 involves the stimulation of structural protein synthesis and reinforcement of dermal-epidermal junction (DEJ) integrity, which declines with age. By strengthening the DEJ, this peptide promotes better nutrient exchange between dermal and epidermal layers, supporting optimal cellular metabolism and renewal.

In cosmetic peptide research, Acetyl tetrapeptide-2 has been widely used in formulations designed for firming, lifting, and contouring applications. Its compatibility with various delivery systems—including serums, creams, and emulsions—makes it an ideal component for anti-aging skincare formulations. Moreover, its biomimetic nature ensures excellent biocompatibility and skin tolerance, allowing it to integrate seamlessly into advanced dermocosmetic products.

Beyond its structural benefits, Acetyl tetrapeptide-2 contributes to the skin’s immune protection by reducing thymic factor loss, a process associated with immunosenescence in aging skin. This dual action—on both structural integrity and biological defense—positions Acetyl tetrapeptide-2 as a multifunctional peptide for modern cosmetic science.

In vitro studies have demonstrated that Acetyl tetrapeptide-2 enhances the stiffness of HaCaT cells (human keratinocytes) and increases their ability to maintain barrier integrity under stress. This translates to improved skin firmness and reduced signs of laxity, particularly in areas such as the jawline, neck, and cheeks.

The peptide also serves as a stimulator of glycosaminoglycan synthesis, contributing to hydration and dermal volume restoration. As a result, Acetyl tetrapeptide-2 delivers a visible lifting and volumizing effect, complementing the benefits of other anti-aging actives such as peptides, antioxidants, and retinoids.

In conclusion, Acetyl tetrapeptide-2 is a high-performance bioactive ingredient for cosmetic peptide research focused on structural restoration, anti-aging, and dermal firmness. Its multifunctional effects on collagen synthesis, skin elasticity, and immune protection make it an essential candidate for advanced anti-aging formulations and cosmetic biotechnology research.

Product Specifications

Mechanism of Action

Acetyl tetrapeptide-2 works by mimicking natural biochemical signals that regulate skin firmness and resilience. It targets the extracellular matrix remodeling process, increasing collagen and elastin synthesis while reducing the degradation of these critical proteins.

The peptide enhances the expression of integrins and laminin-5, improving dermal-epidermal adhesion. This improved adhesion restores skin density and smoothness, leading to visibly firmer skin texture.

Furthermore, Acetyl tetrapeptide-2 acts on fibroblasts to boost the production of structural macromolecules, including collagen type I, III, and elastin, all of which are essential for maintaining dermal strength. It also regulates gene expression associated with matrix metalloproteinases (MMPs), preventing excessive ECM breakdown.

Its role in counteracting thymic involution helps maintain immune homeostasis within skin tissues, protecting against inflammation and oxidative stress. Collectively, these actions translate into reduced fine lines, enhanced elasticity, and a rejuvenated skin appearance.

Side Effects

Acetyl tetrapeptide-2 has demonstrated excellent dermal compatibility in in vitro and in vivo studies. It is considered safe and non-irritating for topical applications at research-relevant concentrations. No significant adverse effects such as erythema, sensitization, or cytotoxicity have been reported in cosmetic peptide studies.

As with all bioactive peptides, standard laboratory precautions should be followed. Direct human application is not recommended as this product is strictly intended for research use only.

Keywords

Acetyl tetrapeptide-2, anti-aging peptide, collagen stimulator, elastin synthesis, firming peptide, skin elasticity peptide, cosmetic raw material manufacturer, peptide wholesale China, high-purity cosmetic peptides, OEM & bulk peptide production.

Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.