Description

Product Description

Tripeptide-41, also known as CG-Lipoxyn, is a synthetic tripeptide with significant research potential in the field of cosmetic peptide science. Identified by the CAS number 1093241-16-7, this compound has gained attention for its lipolytic, anti-fat, and skin-firming properties. Tripeptide-41 is widely studied as an active cosmetic ingredient for research formulations that aim to regulate lipid metabolism, promote collagen remodeling, and improve dermal structure.

As a signal peptide, Tripeptide-41 activates the NF-κB signaling pathway, inhibits the expression of C/EBP, and increases cyclic adenosine monophosphate (cAMP) levels in cells. These processes contribute to lipolysis—the breakdown of lipids into free fatty acids and glycerol—thereby reducing the accumulation of subcutaneous fat. Because of these characteristics, Tripeptide-41 is highly relevant to body contouring, cellulite reduction, and firming peptide research.

In laboratory settings, Tripeptide-41 is often used in formulations designed to simulate dermal metabolism, promote microcirculation, and regulate inflammatory responses related to adipocyte differentiation. This peptide is particularly favored in cosmetic raw material research, especially among peptide manufacturers and peptide suppliers in China, due to its stable performance and compatibility with other actives such as caffeine, acetyl hexapeptide-8, and carnitine.

Researchers have noted that Tripeptide-41’s mechanism also enhances cellular energy turnover, leading to a visible firming effect in in-vitro skin models. Studies have suggested that repeated topical exposure to Tripeptide-41 may support extracellular matrix stability and maintain the integrity of collagen and elastin networks.

From a formulation standpoint, Tripeptide-41 demonstrates excellent solubility and stability in aqueous systems, making it suitable for inclusion in anti-aging serums, slimming gels, and cellulite reduction creams designed for laboratory testing or in-vitro cosmetic research. Because of its low molecular weight, the peptide can penetrate the skin barrier efficiently in experimental settings, allowing researchers to observe dermal-level activity without requiring delivery enhancers.

The peptide is also frequently produced as a lyophilized  form to ensure high stability and purity. Reconstitution in sterile water or buffer before laboratory use maintains structural integrity. As a high-purity peptide (≥99%), Tripeptide-41 from verified China peptide manufacturers ensures consistency across batches and suitability for scientific research applications.

In addition, its cost-effectiveness and reliable quality make it a popular option for bulk peptide powder procurement and OEM peptide production from China peptide factories. Many peptide wholesale suppliers and research peptide manufacturers offer Tripeptide-41 as part of their cosmetic peptide portfolios for laboratory use only.

In cosmetic science research, Tripeptide-41 plays a critical role in exploring how signal peptides regulate adipocyte metabolism. Through controlled experiments, it has been shown to stimulate lipolysis-related enzymes and to help balance energy storage in adipose tissues. Its involvement in the cAMP pathway aligns with its ability to trigger the hydrolysis of triglycerides into glycerol and free fatty acids—a hallmark of lipolytic activity.

Tripeptide-41’s growing reputation as an anti-fat, firming, and rejuvenating peptide positions it as a valuable subject of study for skin elasticity and contour-improving peptide research.

Product Specifications

Mechanism of Action

Tripeptide-41 functions as a lipolytic signal peptide, primarily modulating lipid metabolism through intracellular signaling cascades. It operates by activating the NF-κB signaling pathway and inhibiting the transcription factor C/EBP, both of which are crucial regulators of adipocyte differentiation and lipid storage.

When NF-κB is activated, it enhances the transcription of genes associated with energy metabolism and cellular stress responses. Simultaneously, Tripeptide-41 increases cyclic adenosine monophosphate (cAMP), a secondary messenger that drives the activation of protein kinase A (PKA). This chain reaction leads to the activation of hormone-sensitive lipase (HSL), which catalyzes the hydrolysis of triglycerides stored within adipocytes.

As a result, lipolysis occurs—freeing fatty acids and glycerol for cellular energy consumption. In in-vitro models, this process mimics how adipose tissues regulate lipid storage, thereby reducing visible fat accumulation. These biochemical events suggest that Tripeptide-41 may help restore balance to adipocyte metabolism and mitigate hypertrophic adipogenesis.

Furthermore, Tripeptide-41 exerts anti-inflammatory activity by downregulating pro-inflammatory cytokines such as IL-6 and TNF-α, which are often associated with localized inflammation and tissue remodeling. This dual action—lipolytic and anti-inflammatory—makes the peptide a promising tool in cosmetic peptide studies focusing on cellulite and skin firmness.

In cell culture assays, Tripeptide-41 also demonstrates potential to modulate the extracellular matrix by influencing the synthesis of collagen type I and elastin, essential components that maintain skin elasticity and tone. This aligns with its observed firming effects in research applications.

Side Effects

In research applications, Tripeptide-41 has demonstrated low cytotoxicity and good biocompatibility. No significant adverse effects have been reported in cell culture or in-vitro skin model studies. However, as with any experimental material, proper laboratory safety protocols should be followed.

Potential side effects observed in vitro (at high concentrations) may include transient cellular stress or altered metabolic rates due to overstimulation of lipolytic pathways. Researchers should therefore determine the appropriate dosage based on experimental design, ensuring controlled concentration ranges.

This compound is not approved for medical, cosmetic, or therapeutic use in humans. All testing should be conducted strictly under laboratory conditions.

Keywords

Tripeptide-41, CG-Lipoxyn, lipolytic peptide, signal peptide, anti-cellulite peptide, firming peptide, body contouring peptide, cosmetic peptide supplier, factory peptide supplier, China peptide manufacturer, peptide wholesale China, bulk peptide powder, OEM peptide production, research peptide manufacturer, ≥99% purity peptide.

Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.