Description

Product Description

Hexapeptide-12 (CAS 70592-18-6) is a multifunctional bioactive peptide widely studied in cosmetic and dermatological research for its significant role in enhancing extracellular matrix production, improving skin elasticity, and supporting cellular communication within the dermal layers. As a synthetic fragment that mimics the natural signaling peptides of elastin and fibronectin, Hexapeptide-12 acts as a biological messenger, stimulating fibroblasts to increase collagen and elastin synthesis. This molecular mechanism contributes to restoring skin firmness, reducing wrinkles, and promoting tissue regeneration, making it a valuable compound for advanced cosmetic formulations focused on anti-aging and rejuvenation.

In laboratory research, Hexapeptide-12 demonstrates strong potential in regulating gene expression associated with dermal structure integrity. Studies have shown that this peptide can activate fibroblasts to produce higher levels of structural proteins and glycosaminoglycans (GAGs), key elements responsible for skin plumpness and hydration. Its signal transduction pathway primarily involves binding to cell surface receptors that modulate matrix metalloproteinases (MMPs) and tissue inhibitors (TIMPs), balancing skin remodeling and repair.

Hexapeptide-12’s molecular design allows enhanced bioavailability and stability compared to naturally occurring peptides. This stability is essential for research models exploring topical delivery systems, transdermal penetration, and peptide-based anti-aging formulations. Researchers have observed that when used in combination with antioxidant compounds or other peptides (such as Palmitoyl Pentapeptide-4 or Acetyl Hexapeptide-8), Hexapeptide-12 exhibits synergistic effects, leading to visible improvements in firmness and elasticity under laboratory conditions.

The peptide’s mechanism aligns with its potential in dermal matrix reinforcement, supporting collagen I, III, and IV synthesis, as well as elastin fiber reorganization. These combined activities make Hexapeptide-12 an ideal candidate for experimental use in anti-aging, wrinkle reduction, and skin regeneration studies. Its structural mimicry of fibronectin-derived sequences enhances dermal-epidermal adhesion, improving skin resilience against mechanical stress and age-related degradation.

Furthermore, Hexapeptide-12 has been shown to improve skin barrier recovery by stimulating keratinocyte communication, promoting faster repair of damaged tissue. This bioactivity supports ongoing research in post-procedure recovery formulations, tissue regeneration, and cutaneous repair models. In controlled in vitro studies, Hexapeptide-12 increases the synthesis of extracellular matrix proteins by up to 50%, confirming its potency as a signal peptide for dermal reconstruction.

Overall, Hexapeptide-12 serves as an advanced model compound for researchers studying anti-aging, dermal regeneration, and cellular signaling in skin biology.

Product Specifications

Mechanism of Action

Hexapeptide-12 acts as a biomimetic signal peptide that mimics natural fragments of elastin and fibronectin. It binds to specific receptors on fibroblasts, initiating signal transduction pathways that promote the synthesis of collagen, elastin, and fibronectin. By stimulating these extracellular matrix components, Hexapeptide-12 restores dermal density and structural integrity.

This peptide activates TGF-β and integrin-mediated pathways, leading to enhanced fibroblast proliferation and extracellular matrix deposition. It also modulates MMPs and TIMPs, maintaining a balance between matrix degradation and synthesis, which is crucial for tissue remodeling. The peptide’s molecular sequence enables it to penetrate skin layers effectively and deliver signaling messages that rejuvenate cellular behavior.

In experimental systems, Hexapeptide-12 boosts the production of hyaluronic acid and other GAGs, contributing to hydration and elasticity. It also reduces oxidative stress markers, indirectly supporting antioxidant defense mechanisms. These properties position Hexapeptide-12 as a potent agent in anti-aging and skin repair research.

Side Effects

In research environments, Hexapeptide-12 is generally considered well-tolerated and stable. No cytotoxicity or irritation has been reported at experimental concentrations. However, as with all laboratory materials, researchers should handle this compound under standard biosafety conditions and avoid direct human or animal application.

Keywords

Hexapeptide-12, CAS 70592-18-6, bioactive peptide, anti-aging research, collagen synthesis peptide, cosmetic peptide supplier, high-purity peptide, OEM peptide production, peptide wholesale China, factory peptide supplier

Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure Hexapeptide-12 product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We Hexapeptide-12 provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All Hexapeptide-12 products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.