Description

Product Description

Myristoyl tetrapeptide-12 is a synthetic biomimetic peptide widely studied for its role in hair growth and eyelash enhancement research. Structurally, it consists of a tetrapeptide backbone conjugated to a myristoyl fatty acid chain, which improves dermal penetration and peptide stability. This lipophilic modification allows the compound to effectively reach the hair follicles and the basal layer of the epidermis, where it can interact with cellular signaling pathways responsible for growth and differentiation.

Research on Myristoyl tetrapeptide-12 has demonstrated its ability to directly activate SMAD2 and induce SMAD3-DNA binding, processes that play critical roles in transforming growth factor-beta (TGF-β) signaling. This pathway regulates various cellular processes, including proliferation, differentiation, and extracellular matrix remodeling—key mechanisms in maintaining healthy skin and hair follicles.

In cosmetic science, Myristoyl tetrapeptide-12 has become a focal ingredient for formulations targeting hair density and eyelash volume enhancement. Laboratory findings suggest that it can stimulate keratin synthesis, enhance fibroblast activity, and improve the structural integrity of the dermal matrix. These effects collectively contribute to stronger, thicker, and more resilient hair strands.

The peptide’s biomimetic activity makes it a popular candidate for research on anti-aging, hair regeneration, and eyelash care. Scientists have noted that Myristoyl tetrapeptide-12 may help counteract oxidative stress and inflammation within hair follicles—two major contributors to premature hair loss and follicular miniaturization. In vitro data also point to enhanced cell adhesion molecule expression, improving anchorage of hair shafts within follicles and reducing shedding.

As a research-grade cosmetic peptide, Myristoyl tetrapeptide-12 is commonly utilized in studies that seek to understand the molecular basis of hair cycle regulation. It can be incorporated into formulations mimicking leave-on serums, eyelash conditioners, and scalp tonics designed for laboratory modeling of peptide-induced follicular stimulation.

Product Specifications

Mechanism of Action

Myristoyl tetrapeptide-12 functions as a SMAD2/3 pathway activator, a critical signaling axis involved in TGF-β–mediated cellular differentiation. By directly activating SMAD2 and promoting the formation of SMAD3-DNA complexes, this peptide enhances transcriptional activity related to growth factors, extracellular matrix components, and adhesion molecules.

1. Activation of SMAD Signaling

The SMAD family proteins are intracellular mediators of TGF-β signaling. Upon activation, SMAD2/3 translocate into the nucleus and regulate gene expression associated with tissue regeneration. Myristoyl tetrapeptide-12 has been shown to promote these events, effectively mimicking natural growth factors that stimulate hair follicle stem cell activation and keratinocyte differentiation.

2. Stimulation of Keratinocyte and Fibroblast Function

Keratinocytes and fibroblasts form the core cellular network supporting hair follicles and the dermal extracellular matrix. Research shows that Myristoyl tetrapeptide-12 enhances fibroblast proliferation and increases synthesis of structural proteins like collagen and fibronectin. These activities strengthen the scalp’s dermal foundation and provide a supportive microenvironment for hair shaft growth.

3. Promotion of Eyelash and Hair Growth

Laboratory studies have highlighted the potential of Myristoyl tetrapeptide-12 to enhance eyelash length and density. It does so by upregulating genes involved in follicular differentiation and anchorage. The peptide also supports improved blood microcirculation in the dermal papilla, which ensures adequate nutrient delivery to the growing follicle.

4. Antioxidant and Anti-inflammatory Support

Oxidative stress and inflammation contribute significantly to hair follicle aging. Myristoyl tetrapeptide-12 has been found to increase the expression of antioxidant enzymes, reduce reactive oxygen species (ROS), and downregulate inflammatory cytokines, thereby preserving the longevity and vitality of follicles.

5. Barrier Reinforcement and Scalp Health

In addition to follicular stimulation, Myristoyl tetrapeptide-12 enhances the production of structural lipids and proteins that fortify the scalp barrier. This helps maintain optimal hydration, reduces transepidermal water loss, and supports a balanced scalp microbiome — all of which are essential for healthy hair growth research models.

Side Effects

As a cosmetic research peptide, Myristoyl tetrapeptide-12 is generally considered safe when used under controlled laboratory conditions. Studies have not reported cytotoxicity or irritation at concentrations typically employed in cell culture or ex vivo assays.

Potential side effects under improper conditions may include:

• Mild skin sensitivity at excessive concentrations

• Temporary redness due to overexposure in patch tests

• Peptide degradation if improperly stored or handled

When used in compliance with standard laboratory protocols, Myristoyl tetrapeptide-12 demonstrates a strong safety profile. It is non-genotoxic, non-irritating, and non-sensitizing in experimental models. Researchers are advised to handle it according to institutional safety procedures, using gloves and protective gear.

Keywords

Myristoyl tetrapeptide-12, hair growth peptide, cosmetic peptide, eyelash enhancement peptide, biomimetic peptide, trichology research, peptide supplier China, high-purity peptide powder, cosmetic raw material manufacturer, ≥99% purity.

Shipping Guarantee

All Myristoyl tetrapeptide-12 shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure Myristoyl tetrapeptide-12 product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide Myristoyl tetrapeptide-12 flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All Myristoyl tetrapeptide-12 products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.