Description

Product Description

Palmitoyl tripeptide-38, also known as Matrixyl synthe’6, represents a significant evolution in peptide-based anti-aging research. It is a synthetic signal peptide derived from lysine and other amino acids, specifically designed to promote extracellular matrix synthesis and dermal regeneration. As a bioactive peptide, Palmitoyl tripeptide-38 activates key biological pathways that stimulate collagen, laminin, and hyaluronic acid production — crucial elements for maintaining youthful and resilient skin.

In cosmetic research, Palmitoyl tripeptide-38 functions by boosting the synthesis of six major skin matrix components: Collagen I, III, IV, fibronectin, hyaluronic acid, and laminin-5. These components work synergistically to improve tissue density and reduce the visibility of fine lines and wrinkles. Studies have shown that regular topical application of formulations containing this peptide leads to visible improvements in skin smoothness and structure.

From a molecular biology perspective, Palmitoyl tripeptide-38 mimics natural matrikines, signaling molecules that regulate cellular activities in the extracellular matrix (ECM). Through cell communication mechanisms, it helps reestablish proper matrix remodeling and repair. This mechanism makes Palmitoyl tripeptide-38 highly valuable for dermatological research focused on photoaging, skin elasticity loss, and barrier damage.

In addition to its structural benefits, this peptide exhibits anti-inflammatory and antioxidant effects, which further protect the skin from oxidative stress and environmental aggressors. Researchers studying oxidative pathways and stress-induced cellular senescence often utilize Palmitoyl tripeptide-38 as a model compound due to its ability to restore dermal homeostasis.

Palmitoyl tripeptide-38 is often compared to its predecessor Palmitoyl pentapeptide-4 (Matrixyl), but with a more potent and targeted mechanism. It directly influences ECM regeneration and skin biomechanical properties, leading to faster wrinkle reduction results in experimental models.

As a result, it has become an essential ingredient in cosmetic raw material manufacturing, anti-aging formulation development, and peptide-based skincare research. It is frequently studied alongside other synergistic peptides like Palmitoyl tripeptide-1, Palmitoyl hexapeptide-12, and Acetyl hexapeptide-8, which collectively form part of the advanced peptide research platform used by cosmetic raw material suppliers and peptide manufacturers worldwide.

With its excellent safety profile, stability, and strong affinity for skin cells, Palmitoyl tripeptide-38 continues to be a model compound for exploring cosmetic peptide biochemistry, ECM synthesis regulation, and anti-aging peptide mechanisms in skin biology.

Product Specifications

Mechanism of Action

Palmitoyl tripeptide-38 works by stimulating the synthesis of key matrix proteins in the dermal and epidermal junction. It activates fibroblasts through cell-signaling pathways that lead to increased production of collagen types I, III, and IV, fibronectin, and hyaluronic acid. These molecules are essential to skin integrity, elasticity, and hydration.

The peptide functions as a matrikine, meaning it mimics natural fragments of ECM proteins that regulate cell activity. By interacting with fibroblast receptors, it initiates the transcription of genes involved in matrix regeneration. Research suggests that Palmitoyl tripeptide-38 upregulates TGF-β (Transforming Growth Factor Beta) and integrin-linked kinases, promoting tissue repair and reducing the breakdown of collagen by inhibiting MMP (matrix metalloproteinases) enzymes.

Moreover, Palmitoyl tripeptide-38 enhances communication between keratinocytes and fibroblasts. This cross-talk is crucial for maintaining dermal thickness and smoothness. In studies simulating UV-induced photoaging, cells treated with this peptide showed a 50% increase in collagen deposition and reduced expression of inflammatory cytokines such as IL-6.

The overall result is a restructuring effect at the cellular level — skin regains firmness, elasticity, and resistance to mechanical stress. This makes Palmitoyl tripeptide-38 a vital model compound in skin repair and aging research.

Its anti-wrinkle mechanism is not limited to surface-level hydration or temporary tightening but involves deep biological remodeling of the extracellular matrix, making it an ideal active molecule for long-term anti-aging research studies.

Side Effects

In research conditions, Palmitoyl tripeptide-38 demonstrates excellent biocompatibility and minimal cytotoxicity at standard laboratory concentrations. No significant irritation, mutagenicity, or phototoxic effects have been observed in in vitro and in vivo models.

However, as with all peptides, inappropriate storage or high concentrations can lead to protein denaturation or oxidative degradation, which may affect experimental results. Researchers are advised to store the lyophilized form at -20°C and avoid repeated freeze-thaw cycles.

When handling the compound, laboratory safety guidelines should be strictly followed, including the use of gloves and eye protection. It is not intended for human or animal administration and should be used exclusively for cosmetic and biochemical research purposes.

Keywords

Palmitoyl tripeptide-38, Matrixyl synthe’6, anti-aging peptide, collagen synthesis peptide, cosmetic peptide supplier, skin rejuvenation peptide, wrinkle reduction, peptide wholesale China, high-purity peptide manufacturer, OEM peptide production, cosmetic raw material supplier, factory peptide supplier, research-grade peptide powder.

Shipping Guarantee

All Palmitoyl tripeptide-38 shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We Palmitoyl tripeptide-38 ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We Palmitoyl tripeptide-38 provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All Palmitoyl tripeptide-38 products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.