Description

DPDPE, full name Tyr-D-Pen-Gly-Phe-D-Pen, is a synthetic, cyclic enkephalin analog developed in the early 1980s. Its replacement of methionine or leucine with D-penicillamine at positions 2 and 5 forms a disulfide bond (cyclized), conferring high stability and receptor selectivity. It acts as an exceptionally selective ?-opioid receptor (DOR) agonist, with minimal interaction with ? or ? receptors, making it an invaluable tool in the study of pain modulation, receptor pharmacology, and central nervous system dynamics. With a molecular weight of 645.79 Da and a molecular formula of C??H??N?O?S?, DPDPE is supplied as a white to off-white lyophilized powder, purified to a minimum of 99.83%, and produced under GMP conditions for high experimental consistency.

Product Category

Neuropeptide Receptor Agonists — peptides designed to activate opioid receptors with high specificity, commonly used in neuropharmacological and analgesia-related research.

Product Specifications

Mechanism of Action & Research Applications

DPDPE is a prototype ?-opioid receptor agonist that engages DORs with high affinity and specificity, while sparing ? and ? receptors—ideal for dissecting ?-specific pathways. In vitro, it inhibits electrically induced contraction of mouse vas deferens with an EC?? of ~5.2 nM; in vivo, it demonstrates robust antinociceptive effects. This makes DPDPE a standard in research on pain control, opioid receptor diversity, CNS signaling, and analgesic mechanism investigation. Its stability and selectivity support studies ranging from receptor binding characterization to behavioral pharmacology.

Side Effects (For Research Context Only)

In experimental systems, DPDPE exhibits standard opioid agonist effects, such as modulation of nociception and potential suppression of reflex response. Chronic or high-dose use may influence CNS processing or receptor expression. There is low risk of off-target interaction, but diligent monitoring and dose titration are recommended.

Logistics Transportation

Our shipments are fully insured and handled with expedited care to ensure timely and safe delivery. In the unlikely event of loss, detention, or damage, we provide 100% compensation to guarantee satisfaction and peace of mind.

Disclaimer

DPDPE is for laboratory research use only—it is not approved for therapeutic, veterinary, clinical, or diagnostic applications. Use in humans or animals is strictly prohibited.